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EN
Exon 41 was replaced with a floxed modified exon 41 with nucleotide substitutions (GGG to TCG) that result in the amino acid substitution of serine for glycine at position 2019 (G2019S), mimicking a mutation found in some late-onset autosomal dominant Parkinson's Disease patients. An FRT-flanked neo cassette inserted downstream of the modified exon 41 was removed by flp-mediated recombination. The predicted protein is kinase enhanced. (J:176679)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
