An inverted neo cassette was inserted upstream of exon 4 and a loxP site was inserted downstream of exon 5 via homologous recombination. Cre mediated recombination removed the neo cassette leaving exons 4 and 5 floxed. (J:176655)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count