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A targeting vector was generated to insert an IRES-NLS-cre cassette with an Frt-flanked PGK-neo sequence into the Noto locus, replacing exon 2, in G4 ES cells. Correctly targeted cells were used to produce founder chimeras that were crossed to CD1 (ICR) animals for germline transmission. Resulting animals were crossed to the Tg(ACTGLPe)9205Dym line to delete the PGK-neo. (J:177256)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
