Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}

The Thy1 regulatory sequence directs expression of a fusion protein of the pre-pro-peptide of murine thyrotropin releasing hormone and the N terminus of the modified human amyloid beta polypeptide, Abeta(Q3?42). This transgene expresses an N terminally truncated A beta protein that is glutamate to glutamine modified at position 3 and engineered to liberate its product preferentially within the secretory pathway. Multiple copies of the transgene inserted into position 15.5-16.5 Mbp (based on NCBI Build 36 ) on chromosome 12 resulting in deletion of Trib2. Maximal transgene expression was seen between P12 and P28. (J:176575)