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Cre recombinase was inserted into the 3' end of the locus. All procedures for generating knock-in animals were performed at inGenious Targeting Laboratory (Stony Brook, NY). An internal ribosome entry site (IRES) preceding the cre coding sequence permitted expression of both Shh and cre proteins from the same mRNA. No disruption of endogenous gene activity was detected. (J:171106)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
