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The transgene comprises a yeast artificial chromosome (YAC) from the CEPH Whole Genome MegaYAC Library carrying a 430-kb fragment of DNA from human Chromosome 21 that includes the potassium inwardly-rectifying channel, subfamily J, member 6 gene, KCNJ6 (also called GIRK2, KIR3.2 or HUM21ES123), which is expressed in the brain both in humans and in mice bearing the YAC as a transgene. Line 67 was shown by length-adjusted quantitative Southern blot analysis to bear a single copy of the 430-kb YAC. (J:128897)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
