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The transgene comprises a yeast artificial chromosome (YAC) from the CEPH Whole Genome MegaYAC Library carrying a 475-kb fragment of DNA from human Chromosome 21 containing the genes HLCS (holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)), PIGP (phosphatidylinositol glycan anchor biosynthesis, class P; formerly DSCR5), TTC3 (tetratricopeptide repeat domain 3) and DSCR3 (Down syndrome critical region gene 3). This transgenic line was shown by length-adjusted quantitative Southern blot analysis to bear a single copy of the YAC. (J:128897)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
