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The transgene comprises a yeast artificial chromosome (YAC) from the CEPH Whole Genome MegaYAC Library carrying a 475-kb fragment of DNA from human Chromosome 21 containing the genes HLCS (holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)), PIGP (phosphatidylinositol glycan anchor biosynthesis, class P; formerly DSCR5), TTC3 (tetratricopeptide repeat domain 3) and DSCR3 (Down syndrome critical region gene 3). This transgenic line was shown by quantitative PCR analysis to bear three copies of the YAC. (J:128897)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
