Homologous recombination was employed to insert an Frt-flanked neo cassette followed by an loxP site after exon 2 of Fstl1 and another loxP site before exon 2. Chimeric males were crossed to FVB females, and the offspring were crossed to Flpe deleters to remove the neo cassette, and then crossed to CMV-cre transgenic animals to delete exon 2. (J:176532)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
Insertion, Intragenic deletion
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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