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The transgenic vector contained the cre recombinase sequence and a neo/polyadenylation sequences inserted behind an Acta2 (alpha smooth muscle actin) promoter fragment (from -1010 to about +2582, including exon 1 and part of intron 1 referred to as SMP8). The construct was injected into fertilized F2 eggs from CBA mice. Four founders were obtained and two mice were chosen and crossed to reporter mice, demonstrating smooth muscle-specific cre activity. Line numbers were not indicated. (J:176490)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
