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EN
Duplication of Hoxd11 was accomplished via trans-allelic meiotic recombination (TAMERE): Cre recombinase-mediated recombination occurred in vivo between loxP sites that had been introduced, independently, by homologous recombination in embryonic stem cells into the intergenic region upstream of Hoxd11 on one copy and the intergenic region downstream of Hoxd11 on another copy of Chr 2. The resulting unequal recombination produced the present duplication and a reciprocal deletion of Hoxd11. (J:80090)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
