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A cysteine to arginine amino acid substitution at residue 179 (R179C) of the Gnai2 sequence interferes with the ability of the mutant protein to hydrolyze GTP, rendering it constitutively active. This mutant form of the gene was placed under the control of the tetO promoter in these transgenic mice. A second construct expressing bacterial beta-galactosidase (lacZ) under the regulation of a tetO promoter was coinjected with the Gnai2 vector. (J:109030)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
