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A knockdown vector was constructed with a conditional Rnu6 (U6) promoter (disrupted by insertion of a loxP-flanked neo cassette) driving short hairpin RNA specific for mouse Bccip. The construct was injected into FVB/N fertilized oocytes. Two founder lines (4 and 13) were generated. Line 4 was analyzed to a greater extent. Cre recombination will excise the floxed neo cassette, reconstitutng activity of the Rnu6 promoter and allowing transcription of the anti-Bccip shRNA resulting in RNA interference of the Bccip gene. (J:176115)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
