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A genomic fragment, including exons 1and 2, intron 1 and part of intron 2, was replaced with an EGFP gene and a floxed neo cassette via homologous recombination. In heterozygous mice EGFP expression recapitulates endogenous gene expression. Immunohistochemical analysis confirmed the absence of wild-type protein expression in the ventral midbrain of homozygous embryos at E11.5. (J:175535)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
