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Homologous recombination was used to insert a G to A mutation at nucleotide 1465 (resulting in an aspartic acid to asparagine substitution at position 489) and a floxed neo cassette. Western blot analysis of myoblasts from homozygous mice indicated very low levels of expression. However, RT-PCR analysis indicated mRNA expression levels similar to wild-type controls. (J:175798)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
