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Exon 12 was replaced with a mutated version where cysteine codon 462 (TGT) was changed to alanine (GCT) (p.C462A) and a neomycin resistance gene cassette was inserted into intron 11. RT-PCR analysis confirmed the expression of the mutant transcript. This mutation interferes with binding to Mdm2. Immunohistochemical analysis indicates protein expression is increased in homozygous embryos compared to heterozygous or wild-type mice. (J:174359)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
