The open reading frame, contained entirely in exon 3, was replaced by a cassette composed of rtTA2S*M2, an IRES and a lacZ-SV40 polyadenylataion signal, followed by a floxed PGK-new selection gene. Western blot analysis confirmed the absence of protein in the testes. (J:166982)
Basic Information
(C57BL/6 x 129S4/SvJae)F1
Insertion, Intragenic deletion
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count