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The coding region was replaced with a mutated version with a T to C exchange at nucleotide 845 (coding for a methionine to threonine transition at codon 282), and an IRES, lacZ gene with a nuclear localization signal and FRT flanked neo cassette were inserted via homologous recombination. Flp mediated recombination removed the neo cassette. LacZ expression coincides with endogenous gene expression. Homozygous and heterozygous mice show a reduction in GJC2 positive puncta in the brain and the mutant protein lacks the typical gap junctional immunosignals at oligodendrocytic somata. (J:174197)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
