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A loxP site flanked puromycin resistance gene/transcription stop cassette was inserted into intron 1 and mutations were created in exon 2 altering codon 25 from leucine to glutamine (p.L25Q) and codon 26 from tryptophan to serine (p.W26S). Further changes in exon 4 altered codon 53 from phenylalanine to glutamine (p.F53Q) and codon 54 from phenylalanine to serine (p.F54S). Both transactivation domains are incapacitated once the stop sequences are removed by cre expression. (J:173395)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
