An approximately 4 kb fragment, including exons 7 - 9 encoding for the POU homeodomain and a part of the POU?specific domain, was replaced with a tk-neo cassette via homologous recombination. In situ and immunohistochemical analysis indicated the expression of a truncated mRNA in a small population of basal cells and the absence of the a isoform of the protein in the taste buds of homozygous mice. (J:173905)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
Insertion, Intragenic deletion
--
1
--
21

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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