A loxP site within intron 2 and the neomycin cassette flanked by Frt sites and an additional loxP site within intron 3 are inserted by homologous recombination. The conditional allele was generated by breeding with a germline Flp deleter strain Gt(ROSA)26Sor to delete the Neo cassette leaving a single loxP and Frt sites in intron 3. Although the cre-mediated deletion is predicted to result in the production of an in-frame transcript, the gene product from this allele is predicted to be non functional. (J:168155)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
Insertion, Intragenic deletion
--
1
3
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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