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A dominant-negative mutation of a human cDNA encoding S218A, S222A, and K97A amino acid residue substitutions was placed under the control of TRE2 (tetO) regulatory elements. The purified construct was then injected into nuclei of one-celled embryos. (J:174339, J:174340)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
