Exons 2 - 4 were flanked with wild-type and mutant loxP sites, an inverted IRES-lacZ cassette was inserted between exons 4 and 5 inside the loxP sites, and an FRT flanked neo cassette was inserted between exons 4 and 5 outside the loxP sites via homologous recombination. (J:173575)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count