A loxP site was inserted upstream of exon 1 and a loxP-flanked PGKneo cassette site was inserted downstream of exon 5. Cre-mediated recombination removed the neo cassette and exons 1 through 5. (J:106419)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count