Exons 4 and 5 were flanked by loxP sites and an FRT flanked neomycin selection cassette was inserted in intron 5 downstream of one of the loxP sites. The neo cassette was subsequently removed by crossing to flp expressing mice. (J:173884)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count