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The targeted mutation modified the splice donor for exon 2B so that it became non functional but did not modify any of the encoded amino acids. In addition, codon 73 was modified to encode for Ala. A floxed neomycin selection cassette was inserted as well. The selection cassette was subsequently removed by cre excision. This allele forcibly includes exon 2B as it can no longer be alternatively spliced. (J:182722)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
