A partial Six1 coding sequence was replaced by homologous recombination with the cre-ALPP (human placenta alkaline phosphatase) sequence linked to an internal ribosomal entry site (IRES)) dicistronic reporter and a PGK-neo selection gene. The allele is a functionally-null allele. (J:172023, J:178455)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
Insertion, Intragenic deletion
--
1
6
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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