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Nucleotides substitutions in exon 14 result in the amino acid substitution of arginine for lysine at position 421 (K421R). This mutation responds to the human mutation K445R that results in the loss of kinase activity. A floxed neo cassette was removed by cre-mediated recombination. (J:173099)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
