The targeting vector contained cDNA coding for a fusion protein of click beetle red (CBR)luciferase and monster GFP (hMGFP), preceded by a floxed stop cassette. The construct was targeted to the Gt(ROSA)26Sor locus in ES cells. Cre excision of the stop cassette in knock-in animals results in activation of the CBR reporter. (J:171829)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count