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EN
The Pak7-Cre-ERT2-bGHpA transgene was designed with a mouse p21 protein (Cdc42/Rac)-activated kinase 7 (Pak7) minimal promoter (-77 to +277), a rabbit beta globin intron (650 bp), a CreERT2 fusion gene (Cre-ERT2), and a bovine growth hormone polyA signal. This transgene was injected into C57BL/6J mouse embryos. To establish founder line 25175, founder mice (F0) were bred to B6.R26-lacZ mutant mice (Gt(ROSA)26Sortm1Sor mutant mice backcrossed to C57BL/6N or C57BL/6J for at least 10 generations. CreERT2-positive::lacZ-positive transgenic mice (F1) were bred to C57BL/6 mice. (J:150856)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
