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This transgene consists of the murine alpha-myosin heavy chain cardiac-specific promoter ligated to the 5' end of the mouse alpha-tropomyosin with a single point mutation (GAG to GGG) corresponding to a glycine substitution for a glutamic acid at codon 180. This region interacts with troponin T. Quantification of the transgene demonstrates that copy number in line 57 is 22 copies. (J:127507, J:172340)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
