A loxP site was inserted upstream of exon 9 and a floxed neo cassette and a 3.6 kb genomic fragment of Fbxw7 including a G to A mutation resulting in an arginine to glutamine substitution at position 482 was inserted after the polyA sequence. (J:172214)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count