A lacZ/neo fusion cassette was inserted in frame 11 bases into the beginning of the second exon, replacing this exon and all of exon3. Western blot analysis confirmed the absence of the large SH3 domain containing isoform and the presence of an about 80-90 kD isoform lacking the SH3 domain in homozygous embryos. (J:161922, J:171883, J:172737)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S5/SvEvBrd
Targeted
Insertion, Intragenic deletion
--
1
1
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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