A lacZ/neo fusion cassette was inserted in frame 11 bases into the beginning of the second exon, replacing this exon and all of exon3. Western blot analysis confirmed the absence of the large SH3 domain containing isoform and the presence of an about 80-90 kD isoform lacking the SH3 domain in homozygous embryos. (J:161922, J:171883, J:172737)
Basic Information
Insertion, Intragenic deletion
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count