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Exon 2 was replaced with a floxed neo cassette via homologous recombination. An alternatively spliced mRNA encoding for a protein lacking the importin beta-binding domain is produced. Only a truncated non-functional protein is found in homozygous mutant testes and mRNA levels are strongly decreased as transcription from testis-specific exon 1A does not occur. (J:171441, J:311959)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
