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A BAC, RP11-35C1, that contains human CD21 and complement receptor 1 (CD35) genes was used to generate transgenic mice. The BAC contains the native human regulatory elements and promoters for CR2 expression. In addition to line 38, lines 18 and 36 were also generated, with line 38 exhibiting the highest expression levels. (J:138376)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
