The luciferase gene, followed by SV40 poly(A) signal sequence, and a loxP site flanked neomycin resistance gene cassette, was inserted into exon 23 before the stop codon, in-frame with the targeted gene coding region. The inserted sequence replaces the endogenous 3' UTR. This creates an allele coding for a chimeric peptide of the endogenous protein fused at the C-terminus to the luminescent marker. (J:171738)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
Insertion
--
1
2
9

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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