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The CAG promoter drives ubiquitous expression of reverse tetracycline transactivator 3 with two mutations: 1) modified to bind to the tetracycline responsive element in the presence of doxycycline and 2) three mutations within the transactivator (S12G, F86Y, and A209T) that increase its sensitivity to doxycycline by 25-fold over the original rtTA without increasing background activity. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:171191)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
