A single loxP site was inserted 5' of exon 1 and a floxed and FRT flanked neo cassette was inserted 3' of exon 1 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 1 floxed. (J:171342)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count