Mice lack the sequence in exon 8 that encodes the AF-2 core (amino acids 543 to 549; LLLEMLD). A floxed neo cassette used for selection was removed by cre-mediated recombination. The expression of a slightly smaller protein was confirmed by western blot analysis on uterus extracts. (J:171276, J:175619, J:206373)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count