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The construct contains a Map2/EGFP fusion gene linked to the chicken beta-actin promoter and a floxed transcription and translation STOP cassette. Cre-mediated excision of the STOP permits expression of the microtubule-specific reporter. Pronuclear injection of the linearized construct resulted in generation of 12 founders. Five of eight founder lines showed reporter expression when crossed to Camk2a-cre mice. One line (F29) was characterized further. This line was estimated to carry 5-10 copies of the transgene. (J:75827)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
