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A loxP site flanked hygromycin resistance gene cassette and a mutated version of exon 12 containing two codon substitutions, p.V488A and p.L490A, were inserted via homologous recombination. The mutations in exon 12 disrupt the interaction between this protein and Cbx1, Cbx5, and Cbx3. Confocal microscopic analysis indicates that the association of the protein with the heterochromatin is disrupted in homozygous embryos at E8.5. (J:170392, J:171108)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
