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A targeting vector was designed to insert a loxP site upstream of exon 20 (alternative splice site 4) followed by a frt-flanked neomycin resistance (neo) cassette, and a second loxP site downstream of exon 20. The less common splice acceptor sequence of exon 20 (TGTTTTTTAAACTTTAAAG) was substituted with a much more common one (TGTTTTTTCGTCTTCCTAG) to make the exon always incorporated in the transcript. (J:170231)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
