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In this transgene construct, the Wnt1 promoter drives lacZ cDNA, which is followed by the Wnt1 enhancer. Between the promoter and lacZ sequence is a loxP-flanked PGKneo cassette. This stop cassette prevents expression of lacZ in the absence of cre-mediated recombination. Two lines were obtained. R170 has 2 copies of the transgene, while R44 has 3 copies of the reporter. Both lines displayed the expected Wnt1 pattern after E11.5 when crossed to reporter animals. The R170 line showed stronger recombination activity and was used for further studies. (J:69326)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
