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An IRES LacZ-neo cassette is inserted into exon 14 of the gene and 29 nucleotides are deleted within exon 14 by targeted homologous recombination. The resulting mutation causes C-terminal truncation and partial deletion of DUB active site domain due to a reading frame shift in protein translation. Western blot confirmed absence of protein product in E8.5 embryo. This is a null allele. (J:168184)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
