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A cre recombinase cassette was inserted into the ATG translation start codon of the Phox2b gene contained in a BAC clone by recombineering in bacteria. Correctly recombined clones were injected into C57BL/6J pronucei. Multiple lines were produced and crossed to R26R reporter animals to analyze recombination activity. A line selected for further analysis demonstrating recombination activity in the dorsal motor nucleus of the vagus (DMV) in parasympathetic visceral and brachial motor neurons, with low activity/expression in the nucleus of the solitary tract and area postrema. (J:169562)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
