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The insertion of a construct consisting of a tetracycline operator, CMV promoter, Bmp4 cDNA, IRES lacZ, and FRT flanked pgk-neo cassette, and a poly-adenylation sequence was inserted in place of a 665 bp region that includes the basal promoter and exon1 of the gene. Analysis of p-Smad1/5/8 activity in heterozygous mice indicates this is a hypomorphic allele. (J:169047, J:181229)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
