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This transgene expresses T-121, a truncated form of the SV40 T-antigen that contains the first 121 amino acids. This form inactivates the RB1 protein and the two Rb1-related proteins, RBL1 and RBL2. The transgene is under the control of the mouse Wap promoter. This line carries approximately 10 copies of the transgene.
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
