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A targeting construct containing the eGF/cre/ERT2 (GCE) cassette and an FRT-flanked Kanamycin/neomycin selection cassette was inserted into the consensus start ATG codon of the Upk3a gene in a BAC (RP23-235E13). The PGK-Neo/Kan cassette was removed by transient Flpe-recombinase expression. The resulting BAC transgene was microinjected into (C57BL/6 x DBA) F1 donor eggs. Founder line 26 was subsequently established. Transgene expression is detected in the bladder urothelium and ureters of E15.5 embryos. (J:159099)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
