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Mice bearing this transgene express intracellular, membrane-bound hen egg lysozyme. Expression is driven specifically in melanocytes by the mouse dopachrome tautomerase (Dct; formerly Trp2) promoter. The lysozyme protein is anchored within the endoplasmic reticulum (ER) by the H2-kb transmembrane domain that has been modified by addition of a dilysine ER retention signal. Two transgenic lines, designated TrpHEL1 and TrpHEL2, exhibited similar levels of expression in both skin and thymus, colocalized in skin with endogenous DCT. (J:139546)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
