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The cre recombinase sequence was fused to a nuclear localization signal and inserted between the Lck promoter and the 3' untranslated fragment of the human beta-globin gene in the transgene. The construct was microinjected into male pronuclei of fertilized oocytes. Animals from 2 lines (19,20) were crossed mice carrying a floxed RBP-J allele to determine the activity of the cre transgene. Southern blot analysis of thymocytes from line #19 animals heterozygous for Rbpjtm1Hon showed complete deletion of the floxed locus. (J:168475)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
